Penicillin-Induced Anti-Factor VIII Antibodies: A Case Report

Introduction: Acquired hemophilia A is very rare autoimmune disorder caused by an autoantibody to factor VIII that interferes with its coagulant function. It may be associated a number of conditions such as lymphoproliferative disorders, drugs and solid malignancies. Hemarthrosis in clinical presentation was never reported cases induced penicillin. Case presentation: We report 65-year-old male, born living Brazil, who presented hemorrhagic episodes complicated joint hemarthrosis due acquired commonly used drug, Benzathine penicillin.Disease management focused on controlling bleeding, primarily the use inhibition bypassing activity eradicate using various immunosuppressants. The challenges manage this case included delayed diagnosis, durable remissions, difficulty achieving hemostasis. Clinical laboratory coagulation response has improved eight weeks after only administration double immunosuppression medication: corticosteroid cyclophosphamide. Conclusion: This gives us lesson prompt diagnosis treatment achieved hematologists improve prognosis prevent severe bleeding. Early detection vital improving outcomes.